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Structure and mechanism of the mitochondrial calcium transporter NCLX
Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09491-0Cryogenic electron microscopy structures and functional analyses reveal that NCLX functions as a H+/Ca2+ rather than a Na+/Ca2+ exchanger, and uncover its transport mechanism with implications for therapies treating cardiac and neurodegenerative disorders related to abnormal mitochondrial Ca2+.
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