<i>ABCA7</i> variants impact...

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2025-09-12 21:41:43 -

WWW.NATURE.COM

<i>ABCA7</i> variants impact phosphatidylcholine and mitochondria in neurons

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09520-yLoss-of-function variants of ABCA7, associated with Alzheimers disease, result in disrupted lipid metabolism, mitochondrial function, DNA repair and synaptic signalling pathways in the human brain.

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