Intestinal interoceptive dysfunction drives age-associated...

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2026-03-11 21:16:34 - Translate -

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Intestinal interoceptive dysfunction drives age-associated cognitive decline

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10191-6Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this gutbrain pathway restores memory in aged mice.

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