Proteasome-guided haem signalling axis contributes to T cell...

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2026-03-18 22:17:18 - Traduzir -

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Proteasome-guided haem signalling axis contributes to T cell exhaustion

Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10250-yExhausted CD8+ T cells increase proteasome activity due to the accumulation of depolarized mitochondria, which drives the selective degradation of mitochondrial proteins and releases of regulatory haem through haemoprotein breakdown.

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