A -opioid receptor superagonist analgesic with minimal adverse effects

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Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10299-9N-desethyl-fluornitrazene is a -opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

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