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Prospective evaluation of genomics-guided off-label treatment
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10405-xEvaluation by the Drug Rediscovery Protocol of off-label use of 37 approved cancer drugs on 1,610 patients showed modest activities overall, although subgroups of responders suggest that off-label drug use could be beneficial in tandem with more stringent biomarker selection.
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