Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00691-wA description of the terminology and methodology used in this supplement, and a guide to the functionality that is available free online at natureindex.com.

Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00686-7Integrated care and prevention strategies are key, but without careful planning and sustainable funding they risk falling short.

Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00689-4Denmark and South Korea stand out for their strong cancer strategies while England seeks to get back on track.

Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00690-xA breakdown of publications in the database also reveals the cancer types with the highest output.

Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00688-5Meet the creative minds that aim to improve cancer detection and treatment.

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Federal Reserve Chairman Jerome Powell, right, and President Donald Trump look over a document of cost figures during a visit to the Federal Reserve, Thursday, July 24, 2025, in Washington. (AP Photo/Julia Demaree Nikhinson, File)2026-04-15T13:31:40Z President Donald Trump has again threatened to fire Jerome Powell if the Federal Reserve Chair decides to stay on the central banks governing board after his term as chair expires next month.Well then Ill have to fire him, OK? Trump told Fox Business in an interview that aired Wednesday when reminded that Powell has said he wont leave the Fed while the Justice Department investigates a $2.5 billion renovation project at the bank. Trump has for months wanted to remove Powell as chair of the Fed, saying he has been too slow in orchestrating interest rate cuts that would give the U.S. economy a quick boost. Powell has said the investigation is a pretext to undermine the Feds independence to set rates. A federal prosecutor last month admitted that the investigation into the renovations had turned up no evidence of a crime. Powells term as Fed governor expires May 15, but his term as a Fed board member lasts until January 2028.Trump has nominated former Fed official Kevin Warsh to succeed Powell. Yet Warshs confirmation has been delayed. Sen. Thom Tillis, a North Carolina Republican, has said he wont vote to confirm any Fed nominees until the investigation is dropped.

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The administration has invoked national security in a variety of matters, including the White House ballroom and offshore wind farms, drawing rebukes from some judges.

Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00907-zAn artificial-intelligence system bypasses complex equations to predict the performance of thermoelectric generators.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10416-8A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.

Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01187-3A high-resolution atlas of the healthy human liver has been assembled using gene-expression profiling and spatial mapping of cells in samples from living donors. The atlas reveals human-specific patterns of gene expression in different zones and uncovers spatially resolved adaptations in liver cells from individuals with the disease steatosis.

Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00911-3If general cancer treatment fails, a tumour-type-specific therapy might be tried for other cancers with genetic changes in the targeted pathway. How well does this work?

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10350-9Combined functional ultrasound imaging and Neuropixels recording of mouse brains identify two neuronal populations with opposing arousal-related activity and distinct haemodynamic response functions, that occur throughout the brain.

Do April showers bring May...fantasy points? Some slow fantasy starts might lead to improved production.

Secretary of Health and Human Services Robert F. Kennedy, Jr. speaks during a fireside chat with CPAC Senior Fellow Mercedes Schlapp at the Conservative Political Action Conference (CPAC) in Dallas, Saturday, March 28, 2026. (AP Photo/Gabriela Passos)2026-04-15T13:15:23Z WASHINGTON (AP) The Food and Drug Administration will hold a meeting this summer to consider easing restrictions on more than a half dozen peptide injections, a group of unapproved therapies that have become popular among wellness influencers, fitness gurus and celebrities.The meeting announcement Wednesday follows repeated pledges by Health Secretary Robert F. Kennedy Jr. to loosen regulations on peptides, which are often pitched as a quick way to build muscle, heal injuries or appear younger. Theres little research behind those claims and most peptides have not been reviewed for safety by the FDA.Kennedy has discussed using peptides for his own injuries. And some major supporters of his Make America Healthy Again movement are big proponents of them, including Gary Brecka, a self-described longevity expert who sells various peptide formulas through his website. The FDA said in a federal notice Wednesday it will ask a panel of outside advisers to review seven peptides at a meeting in July, specifically whether they should be removed from a restrictive category reserved for risky, customized drugs. The peptides under discussion will include some of the most popular among influencers, such as BPC-157, which is marketed to heal injuries and reduce inflammation. The Wild West is about to become wilder, said Dr. Peter Lurie, a former FDA official who now leads the Center for Science in the Public Interest. In an interview, Lurie said allowing peptides on the market without clinical testing poses a profound threat to FDAs decades-old system for vetting drugs. Read More I dont see why one would take the path of a proper drug approval if there is now this less rigorous, alternative path to market, he said.Under President Joe Biden, the FDA added nearly 20 of the most popular peptides to the federal list of substances that should not be produced by compounding pharmacies businesses that mix medications that arent available from drugmakers. At the time, the FDAs panel of pharmacy advisers voted overwhelmingly that the peptides did not meet the criteria for a list of drugs that can be safely compounded. And FDA regulators agreed, saying later that the substances present significant safety risks, because most have not been extensively tested in humans.Many of the FDA advisers and internal staff who oversaw those decisions no longer work for the agency. The FDAs pharmacy panel currently has a number of vacancies, which Kennedy could fill before the July meeting.At the FDA meeting in July, panelists will consider whether BPC-157, TB-500 and five other peptides should be permitted for routine compounding. The FDA notice cites several possible medical uses for the substances, such as using BPC-157 to treat ulcerative colitis.Kennedy previewed the move in an interview with podcast host Joe Rogan. Both men have repeatedly spoken about peptides and claimed to have benefited from their use. Sign up for Morning Wire: Our flagship newsletter breaks down the biggest headlines of the day. Email address Sign up By checking this box, you agree to AP's Terms of Use and acknowledge that AP may collect and use your data pursuant to our Privacy Policy. RFK Jr. claims personal benefit from peptides Im a big fan of peptides, Kennedy told Rogan. Ive used them myself and with really good effect on a couple of injuries.Given Kennedys statements, Lurie said it was doubtful the drugs would receive real scrutiny from FDA.Everybody knows the outcome that the secretary wants, Lurie said. I dont believe for one moment that whats going on here is an honest investigation of whether these products should be compounded. Scott Brunner of the Alliance for Pharmacy Compounding said the coming meeting will be the start of a protracted process. Even if the panel votes to make the peptides available, and FDA agrees, the agency will still have to draft and publish rules on the change, he noted.Peptides are essentially the building blocks of more complex proteins. Inside the human body, peptides trigger hormones needed for growth, metabolism and healing.In recent years peptides have become widely known through the blockbuster success of GLP-1 medications, which the FDA has approved for treating obesity and diabetes. Other FDA-approved peptides include insulin for diabetics and hormone-based drugs for several medical conditions. But many of the peptides promoted online have never been approved, making them technically illegal to market as drugs. Several peptides, such as BPC-157 and TB-500, are banned by international sports authorities as doping substances.But that has not stopped them from gaining a foothold in the burgeoning marketplace for new wellness hacks and alternative remedies. In a related move, some dietary supplement makers have begun mixing peptides into capsules, protein powders and gummies. At a recent FDA meeting, the industry argued for expanding the federal definition of supplements to permit the use of newer ingredients like peptides in their products. Safety risks were cited previouslyWhen the FDA added a number of injectable peptides to its list of restricted substances in 2023, it cited safety risks including cancer and liver, kidney and heart problems.That triggered pushback from wellness entrepreneurs, compounding pharmacies and their allies in Washington.Last year several members of Congress, including Republican Sen. Tommy Tuberville of Alabama, sent letters to Kennedy asking him to lift limits on peptide production.The compounding industry has argued for years that FDAs restrictions have given rise to an illicit market of imported chemicals from China and other countries, which are not subject to U.S. drug standards.Kennedy has echoed those concerns.With the gray market you have no idea if youre getting a good product, Kennedy told Rogan. And a lot of this stuff that weve looked at is just very, very substandard.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institutes Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content. MATTHEW PERRONE Perrone covers the intersection of medicine, business and health policy. He is based in Washington. twitter mailto

Cars damaged by Russia's drone attack are seen in Zaporizhzhia, Ukraine, Wednesday, April 15, 2026. (AP Photo/Kateryna Klochko)2026-04-15T10:14:23Z KYIV, Ukraine (AP) Ukraines top diplomatic priority is securing its allies help to buy and build more air defense systems, President Volodymyr Zelenskyy said Wednesday between meetings with European leaders, as Russia kept up its deadly attacks on civilians and public infrastructure.Russian strikes hit more than a half-dozen areas of Ukraine behind the front line from Tuesday to Wednesday, killing an 8-year-old boy in the central Cherkasy region and a woman who was in a kiosk near a bus stop that was hit in southern Zaporizhzhia, according to Zelenskyy and local officials.Every day we need air defense missiles every day Russia continues its strikes, Zelenskyy said in a post on the Telegram messaging app.With no plans announced for further U.S.-mediated talks with Russia, Zelenskyy was visiting three European capitals in 48 hours, securing promises of further military and financial support from Germany and Norway ahead of his trip to Italy on Wednesday. Germany and Ukraine agreed a defense package valued at 4 billion euros ($4.7 billion), and Norway has pledged 9 billion euros ($10.6 billion) in assistance, Ukrainian officials said.After more than four years of fighting Russias full-scale invasion, Ukraine possesses battle-tested drone interceptor expertise and has developed groundbreaking air defense technology, but it lacks the money to scale up production to levels that would press its advantage. Defense leaders from 50 countries aim to send more help to UkraineZelenskyy said he is asking European countries to keep adding money to a fund that allows the purchase from the United States of American-made weapons for Ukraine, especially the Patriot air defense system that can stop Russian cruise and ballistic missiles hitting civilian areas. Between November and March, Russia launched 27,000 Shahed-type drones, nearly 600 cruise missiles and 462 ballistic missiles at Ukraine, Ukrainian Defense Minister Mykhailo Fedorov said.Zelenskyy is also championing joint weapons production agreements, including for drones and missiles, while pushing for the European Union to move quickly on providing a promised 90 billion euro ($106 billion) loan. Defense leaders from the about 50 nations who regularly gather to coordinate weapons aid for Kyiv held an online meeting Wednesday, chaired by German Defense Minister Boris Pistorius and British Defense Secretary John Healey. NATO Secretary-General Mark Rutte also attended.Ahead of the meeting, Britain announced it will send 120,000 drones to Ukraine this year, its biggest delivery of the weapons so far. Officials didnt say how soon they will be sent. Read More Ukraine seeks to keep up its battlefield momentumUkraines war effort has gained momentum in recent weeks, according to Western officials and analysts. Its short-handed troops have disrupted Russias spring offensive, thanks in part to drones and ground robots, and its long-range strikes have dented Russian oil exports and some manufacturing output.Ukraines top military commander Oleksandr Syrskyi said Wednesday that last month Ukrainian troops recaptured nearly 50 square kilometers (20 square miles) of territory from Russian forces. Also in March, Ukrainian deep strike operations hit 76 Russian targets, including 15 oil refining facilities, he said. But clouds have also gathered, as the Iran war drains stockpiles of advanced air defense missiles that Ukraine needs, and Kyivs money is running short.We cannot lose sight of Ukraine amid the Middle East conflict, NATO chief Rutte said. Sign up for Morning Wire: Our flagship newsletter breaks down the biggest headlines of the day. Email address Sign up By checking this box, you agree to AP's Terms of Use and acknowledge that AP may collect and use your data pursuant to our Privacy Policy. Russia fires more than 300 drones at Ukraine civilian areasRussia launched 324 drones and three ballistic missiles at Ukraine overnight, the Ukrainian air force said, in its biggest barrage in almost two weeks. Air defenses intercepted 309 of the drones.Russia also fired a powerful FAB-1500 glide bomb, weighing 1.5 metric tons, at the central part of Sloviansk before dawn Wednesday, the Sloviansk City Military Administration head Vadym Liakh said.The blast destroyed a childrens sports facility that was a city landmark, he said.In a nighttime strike on the southeastern city of Dnipro, Russian forces struck two universities overnight, damaging academic buildings, dormitories and nearby homes, Mayor Borys Filatov said. The blast wave shattered more than 1,000 windows in surrounding buildings, he said, adding that there were no military targets in the area. Meanwhile, Ukraine proceeded with its long-range drone attacks, with the Russian Defense Ministry reporting Wednesday that its air defenses intercepted 85 Ukrainian drones overnight.Ukrainian drones targeted an industrial facility in Sterlitamak, a Russian city about 1,300 kilometers (roughly 800 miles) east of the border with Ukraine, local authorities said.Radiy Khabirov, governor of the Bashkortostan region where Sterlitamak is located, said in an online statement Wednesday that several drones were shot down over Sterlitamaks industrial zone, and debris fell on one of the facilities there, starting a fire. One person died in the attack, he said. ___Associated Press writers Jill Lawless in London, Kirsten Grieshaber in Berlin and Lorne Cook in Brussels contributed to this report.___Follow APs coverage of the war in Ukraine at https://apnews.com/hub/russia-ukraine HANNA ARHIROVA Arhirova is an Associated Press reporter covering Ukraine. She is based in Kyiv. twitter instagram mailto

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10362-5Studies explaining the secondary Igk recombination mechanism are described and Cer/Sis deletion and/or displacement is implicated as a developmental switch converting the rearrangement mechanisms from two-loop-based diffusional primary Igk into one-loop-based linear scanning secondary mechanisms.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10381-2Shelves rather than shorelines may be better topographic indicators of oceans on Earth and Mars.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10379-wMonolithic three-dimensional (3D) integration of tantalum pentoxide on a lithium niobate substrate enables scalable, multifunctional photonic systems and the incorporation of nonlinear optics directly into existing and emerging photonics infrastructure.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10508-5Carbonyl swapping converts cyclic ketones to saturated heterocycles

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10504-9Editorial Expression of Concern: Creation of human tumour cells with defined genetic elements

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10358-1Analysis of 15,836 ancient West Eurasian genomes reveals hundreds of instances of directional selection, showing that sustained changes in allele frequency were widespread, rather than being rare over this period as previously assumed.

Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01181-9A platform for tracking the changes in gene expression and chromatin accessibility that follow interference with specific genes has been developed. The platform, called PerturbFate, was applied to skin-cancer cells and showed that different genetic perturbations associated with tumour resistance push cells into a shared dedifferentiated state.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10386-xThis Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable environmental and endogenous factors to expand tumorigenic clones.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10483-xRetraction Note: The hidden fitness of the male zebra finch courtship song

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10353-6mRNAlipid-nanoparticle vaccines do not require type 1 conventional dendritic (cDC1) cells or the WDFY4-dependent cross-presentation pathway for CD8+ T cell priming but, instead, engage both cDC1 and cDC2 cells redundantly.

Paramedics attach a portrait over the grave of Ghadir Baalbaki, 19, who was killed on Tuesday in an Israeli airstrike, at a temporary mass grave in the southern port city of Tyre, Lebanon, Wednesday, April 15, 2026. (AP Photo/Hussein Malla)2026-04-15T11:59:15Z TYRE, Lebanon (AP) Israel pressed on with bombarding southern Lebanon on Wednesday, a day after historic talks between Lebanese and Israeli officials in Washington. Smoke rose over the coastal city of Tyre, underscoring the fragility of diplomatic efforts.Although Israeli strikes on Beirut have eased since last weeks shattering 10-minute bombardment without warning killed over 350 people across the country, southern Lebanon remains under attack.The Israeli military has periodically issued warnings urging residents to flee wide swathes of southern Lebanon as it targets the Iranian-backed Hezbollah militant group, but tens of thousands of people have stayed either because they dont want to leave their homes or because they have nowhere to go. Tyre, too, is under Israeli evacuation order, but many displaced families had seen it as a refuge of last resort, removed from the heaviest clashes closer to the Israeli border. Increasingly, though, residents say nowhere even in Tyre feels safe. Across the city, the war was visible in shattered buildings, mounds of rubble and debris-strewn streets. Residents moved cautiously along wreckage-lined roads. Mourners gathered for the funeral of 19-year-old Ghadir Baalbaki, killed overnight in an Israeli drone strike just outside Tyres city center. It was not immediately clear who was targeted, but witnesses said Baalbaki had been sitting outside her house when the drone hit nearby. Read More I hugged Ghadir because I thought she had fainted. I kept trying to wake her up, Mariam Hamoud, her aunt, recalled from the temporary graveyard where Baalbaki was buried. Many families cant return to home villages to bury their dead because they are too close to the front lines. Baalbakis father, Mohammed Baalbaki, stood beside the grave in tears. We cannot adapt to life without her, he said.Across southern Lebanon, Israeli forces said they had struck more than 200 Hezbollah targets over the past 24 hours. Hezbollah claimed rocket attacks on military targets in northern Israel and on Israeli forces in the town of Khiam near the border, which has seen intense fighting in recent weeks. Tuesdays talks between Lebanon and Israel in Washington have drawn backlash from Hezbollah and its supporters.Hezbollah lawmaker Hassan Fadlallah on Wednesday castigated Lebanese authorities for what he called the disgraceful image of direct negotiations with Israel at a time when it is killing Lebanese people and committing massacres. He called on the government to hold a popular vote on the future of Hezbollahs arsenal rather than decide its fate in talks with Israel.Lebanons government seeks the disarmament of Hezbollah, but the group has long defied such efforts.If it truly wants to prove it reflects the aspirations of the Lebanese people, then (the government) should accept a public referendum. We are ready for a referendum on these choices, Fadlallah told reporters, saying he expected the results to show that a majority of Lebanese people support Hezbollahs militant activities. On the streets of Beirut, Lebanese were divided on the talks. Some agreed with Hezbollah that Israel can only be stopped through military force.These negotiations do not represent us its as if they never existed, said Mustafa Alaa Al-Din, who was displaced from southern Lebanon.Others welcomed the talks, expressing support for any initiative that promises to hasten the end of the war.The negotiations are more in our interest than in Israels interest because we are the ones whose country is being destroyed, we are the ones suffering losses, said Mohamed Saad, a Beirut resident.The latest Israel-Hezbollah war began when Hezbollah fired missiles across the border days after the U.S. and Israel launched their war on Iran. Israel responded with an intense aerial campaign and ground invasion.At least 2,167 people have been killed in Israeli strikes, Lebanons health ministry said Wednesday, including 260 women, 172 children and 91 medical workers. More than 1 million Lebanese have been displaced.___Associated Press writers Fadi Tawil and Isabel DeBre in Beirut contributed to this report.

FILE -President Donald Trump greets Italy's Prime Minister Giorgia Meloni during summit to support ending the more than two-year Israel-Hamas war in Gaza after a breakthrough ceasefire deal, Oct. 13, 2025, in Sharm El Sheikh, Egypt. (AP Photo/Evan Vucci, Pool, File)2026-04-15T15:26:44Z MILAN (AP) Italian Premier Giorgia Meloni was supposed to be Europes bridge to U.S. President Donald Trump. It may be burning. After chastising Pope Leo XIV, Trump turned his ire on Meloni, long one of his closest European allies, for calling his papal broadside unacceptable and not backing the U.S.-Israel war on Iran. I thought she had courage, Trump said in an interview with leading Italian daily Corriere della Sera. I was wrong.Meloni has not directly responded to Trumps attacks. But they may be to her advantage as she recovers from a decisive referendum defeat last month and as she seeks to dull the impact of the deeply unpopular Iran war, including higher energy prices.I actually think this is a godsend for her, said Nathalie Tocci, a professor at Johns Hopkins SAIS Europe and the director of the International Affairs Institute. Trump has become completely toxic across Europe, across much of the world, including Italy.Trump doubled down on Wednesday, saying their bond had frayed. Shes been negative, Trump told Fox News. Anybody that turned us down to helping with this Iran situation, we do not have the same relationship. The Meloni-Trump arcThe only European Union leader invited to Trumps second inauguration, Meloni was expected to leverage her strong ties with him once he returned to office 15 months ago. The two had a perceived natural alliance, with nationalistic tendencies and similarly hard-line stances on immigration. But Italy was not spared the pain of Trumps tariffs, and some may argue she has gotten little out of the relationship. When asked if they had spoken this month, Trump told Corriere, No, not in a long time.' After an uncomfortable appearance in the Oval Office a year ago when she avoided directly confronting Trump on tariffs, the distance grew over the Iran war. Meloni has stated Italy will not participate in the war and the country last month refused U.S. bombers the authorization to land at a pivotal air base in Sicily. Melonis statement this week calling Trumps attack on the pope unacceptable was the most direct criticism of the president yet.Its been building up over time, not so much because she is moving away from him but because he has become increasingly unhinged, Tocci said. Read More Alliance strained but standingCabinet minister Adolfo Urso, a member of Melonis far-right Brothers of Italy, said U.S.-Italy relations would not be shaken by the flap.Italy and the United States are allied countries and maintain their relationship and alliance within international institutions, starting obviously with the Atlantic Alliance, he told Radio 24, adding that the churchs moral teachings cannot crack relationships consecrated in alliances signed a few decades ago. Mariangela Zappia, president of the ISPI think tank and a former Italian ambassador to the U.S., said Trumps hot-blooded reaction could be attributed to his frustration with Europe, not just Italy. Besides not getting support for the Iran war, Trump lost a strong ally with Viktor Orbns electoral defeat in the Hungarian elections this weekend. Still, she said Trumps personal outburst aimed at Meloni should not be construed as damaging the alliance as a whole.Europe absolutely considers the United States its historic ally, but in some way wants to be involved in the decisions that are taken, Zappia said.Trump, on the other hand, is realizing this European Union is not easy to dismantle, she said. We are different, we react differently. Some are clearly anti-Trump, some are pro-Trump but in the end, destroying the European project, separating us on the things on which we see as our future, that is very difficult. Meloni focused on ItalyMeloni has sought to shore up support after the referendum loss, which became a de facto confidence test of her leadership. She made a two-day whirlwind solo tour of three Gulf states to shore up Italys gas and oil supply from the region during a growing energy crisis but returned home without any formal deals.On Tuesday, she announced Italy would not automatically renew a defense agreement with Israel, after warning shots hit an Italian convoy that is part of the U.N. peacekeeping mission in southern Lebanon, a move that analysts say is driven more by domestic politics than a strategic shift.The Gulf tour was a way to show public opinion that she was being proactive. The fact it didnt actually lead to anything is beside the point, Tocci said. The Israel move substantively is rather meaningless because there is not much in this agreement but symbolically it helps because Israel has become just so unpopular in Italian public opinion.No matter what damage control she has done after the referendum loss, Roberto DAlimonte, a professor at the LUISS school of government, predicts a difficult last year and a half of her mandate before elections due in 2027, largely due to the economic impact of the Iran war.People want to see their gas bills go down, not just see Meloni talk about gas. What matters are the bills you get every month, he said. COLLEEN BARRY Barry covers all things Italy for The Associated Press. Her focus includes fashion and design, overtourism and the environment, politics and sometimes the Vatican. twitter instagram mailto RSShttps://feedx.net https://feedx.site

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10405-xEvaluation by the Drug Rediscovery Protocol of off-label use of 37 approved cancer drugs on 1,610 patients showed modest activities overall, although subgroups of responders suggest that off-label drug use could be beneficial in tandem with more stringent biomarker selection.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10391-0MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10367-0PerturbFate is a high-throughput, cost-effective, single-cell platform that systematically profiles CRISPR interference perturbations to reveal common regulatory nodes and convergent phenotypic states across diverse genetic alterations linked to vemurafenib resistance in melanoma cells.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10377-yA human spatial atlas of gene expression in liver based on live donors shows marked portocentral zonation of hepatocytes and non-parenchymal cells, and transcriptomic changes in early steatosis.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10223-1A composable neural network emulator is described for speeding up thermoelectric generator design, demonstrating the ability to predict generator performance with >99% accuracy while taking only 0.01% of the time compared with commercial finite-element solvers.

The Tigers and rookie shortstop Kevin McGonigle agreed to an eight-year contract extension worth $150 million, the team announced Wednesday.

The post Moonshot Their Wad appeared first on The Onion.

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Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01204-5Data from more than 15,000 ancient people reveal natural selection of hundreds of genes linked to immunity, skin tone, behaviour and other traits.

Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00906-0A large language model that is trained using AI outputs can inherit undesirable behaviours, even if they are not directly referenced in the training data.

Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01224-1Using artificial-intelligence to teach other models can be cheaper and faster than building them from scratch, but this approach can introduce unwanted traits.

Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01241-0Genomics-guided trial could increase options for people undergoing cancer therapy plus, a landmark ancient-genome study reveals natural selection in hundreds of human genes.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10269-1In this Perspective article, a theoretical framework for how the AP-1 family of transcription factors mediates cellular adaptation in cancer drug resistance is proposed.

Mark Rosenblatts Broadway play, starring John Lithgow as the British childrens book author, draws from Dahls comments over the years.

As artificial intelligence makes many tasks easier, the human work of cajoling, arm-twisting and reassuring appears to be rising in importance.