Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03948-yUnpacking risk factors, disease aggressiveness and other key work.

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Members of the California National Guard and U.S. Marines guard a federal building on Tuesday, June 17, 2025, in Los Angeles. (AP Photo/Damian Dovarganes, File)2025-12-10T15:14:42Z The Trump administration must stop deploying the California National Guard in Los Angeles and return control of the troops to the state, a federal judge ruled Wednesday. U.S. District Judge Charles Breyer in San Francisco granted a preliminary injunction sought by California officials who opposed President Donald Trumps extraordinary move to use state Guard troops without the governors approval to further his immigration enforcement efforts. But he also put the decision on hold until Monday.California argued that conditions in Los Angeles had changed since Trump first took command of the troops and deployed them in June. The administration initially called up more than 4,000 California National Guard troops but that number had dropped to several hundred by late October. Only a 100 or so troops remain in the Los Angeles area.The Republican administration extended the deployment until February while also trying to use California Guard members in Portland, Oregon as part of its effort to send the military into Democratic-run cities over the objections of mayors and governors. U.S. Justice Department lawyers said the administration still needed Guard members in the Los Angeles area to help protect federal personnel and property. An email to the White House seeking comment on Wednesdays ruling was not immediately returned. Stay up to date with the news and the best of AP by following our WhatsApp channel. Follow on Trump took command of the California National Guard following protests over his stepped-up enforcement of immigration laws. The call up was the first time in decades that a states national guard was activated without a request from its governor and marked a significant escalation in the administrations efforts to carry out its mass deportation policy. The troops were stationed outside a federal detention center in downtown Los Angeles where protesters gathered and later sent on the streets to protect immigration officers as they made arrests. California sued, and Breyer issued a temporary restraining order that required the administration to return control of the Guard members to California. An appeals court panel, however, put that decision on hold. California argued that the president was using Guard members as his personal police force in violation of a law limiting the use of the military in domestic affairs.The administration said courts could not second-guess the presidents decision that violence during the protests made it impossible for him to execute U.S. laws with regular forces and reflected a rebellion, or danger of rebellion. In September, Breyer ruled after a trial that the deployment violated the law. Other judges have blocked the administration from deploying National Guard troops to Portland, Oregon, and Chicago.

This photo provided by the New York State Sex Offender Registry shows Jeffrey Epstein, March 28, 2017. (New York State Sex Offender Registry via AP, File)2025-12-10T14:58:28Z NEW YORK (AP) Secret grand jury transcripts from Jeffrey Epsteins 2019 sex trafficking case can be made public, a judge ruled Wednesday, joining two other judges in granting the Justice Departments requests to unseal material from investigations into the late financiers sexual abuse.U.S. District Judge Richard M. Berman reversed his earlier decision to keep the material under wraps, citing a new law that requires the government to open its files on Epstein and his longtime confidant Ghislaine Maxwell. The judge previously cautioned that the 70 or so pages of grand jury materials slated for release are hardly revelatory.On Tuesday, a different Manhattan federal judge ordered the release of records from Maxwells 2021 sex trafficking case. Last week, a judge in Florida approved the unsealing of transcripts from an abandoned Epstein federal grand jury investigation in the 2000s. The Justice Department asked the judges to lift secrecy orders after the Epstein Files Transparency Act, passed by Congress and signed into law by President Donald Trump last month, created a narrow exception to rules that normally keep grand jury proceedings confidential. The law requires that the Justice Department disclose Epstein-related records to the public by Dec. 19. Stay up to date with the news and the best of AP by following our WhatsApp channel. Follow on Questions about the governments Epstein files have dominated the first year of Trumps second term, with pressure on the Republican intensifying after he reneged on a campaign promise to release the files. His administration released some material, most of it already public, disappointing critics and some allies. Epstein, a millionaire money manager known for socializing with celebrities, politicians, billionaires and the academic elite, killed himself in jail a month after his 2019 arrest. Maxwell was convicted in 2021 by a federal jury of sex trafficking for helping recruit some of Epsteins underage victims and participating in some of the abuse. She is serving a 20-year prison sentence. In court filings, the Justice Department informed Berman that the only witness to testify before the Epstein grand jury was an FBI agent who, the judge noted, had no direct knowledge of the facts of the case and whose testimony was mostly hearsay.The agent testified over two days, on June 18, 2019, and July 2, 2019. The rest of the grand jury presentation consisted of a PowerPoint slideshow and a call log. The July 2 session, which ended with grand jurors voting to indict Epstein. Both of those will also remain sealed, Berman ruled.___Follow the APs coverage of Jeffrey Epstein at https://apnews.com/hub/jeffrey-epstein. MICHAEL R. SISAK Sisak is an Associated Press reporter covering law enforcement, courts and prisons. He is based in New York. twitter mailto

A Hungarian LGBTQ+ rights activist is being investigated for defying the countrys new ban on Pride events when he organized a massive march in the city of Pcs. In October, a reported eight thousand people showed up to express LGBTQ+ solidarity in the face of hostility from Prime Minister Victor Orbns authoritarian Fidesz party. In April, the party passed a constitutional amendmentoutlawing Pride eventsin the Central European nation and allowing authorities to use facial recognition technology to identify attendees of the banned events. Related Hundreds of thousands turn out for Budapest Pride after authoritarian government banned pride Gza Buzs-Hbel who was fired last year from his state teaching job due to his role in LGBTQ+ activism told The Guardian he and his organization, Diverse Youth Network, still held the march in Pcs because Freedom of assembly is a fundamental human right, and we cannot allow political decisions to limit our communitys visibility or self-expression.If we dont stand up for ourselves here, then where? he said. Pride is not just a march it is a message: queer people exist even when others try to silence or ban us. Never Miss a Beat Subscribe to our newsletter to stay ahead of the latest LGBTQ+ political news and insights. Subscribe to our Newsletter today Since the event, he has been questioned by police, who recommended prosecutors press charges against him. They are currently deciding what to do next. Meanwhile, Buzs-Hbel says he faces a suspended prison sentence of up to three years. He will also be permanently banned from teaching if prosecutors decide to formally charge him. Despite the risks, he has no regrets. None of this changes the fact that I would organize Pride again in exactly the same way and I will do so next year as well, he said. For me, it is not just an event, but a stand for all those who need visibility and courage in such a hostile environment. Freedom sometimes comes at a high price, but the only thing I would truly regret is failing to stand up for my community. He also said hes waiting to see if the European Union, of which Hungary is a member, is ready to stand up for the principles it claims to represent.If, in an EU member state, someone can face criminal prosecution simply for organizing a peaceful Pride march and the EU does not respond firmly it sends the message that European values only matter until defending them requires real political courage.Earlier this year, a group of 20 European member nationsreleaseda letter condemning the legislation. The signatories called on the European Commission to expeditiously make full use of the rule of law toolbox at its disposal if the law isnt overturned. Respecting and protecting the human rights and fundamental freedoms of all people, including LGBTIQ+ persons, is inherent in being part of the European family. This is our responsibility and shared commitment of the member states and the European institutions, the letter read.Like Russia, its ally in a politically motivated campaign against the degenerate West, Hungary has also institutedgay propaganda lawsprohibiting the depiction or promotion of homosexuality to minors. The European Commission started legal action against Hungary in 2021 over the law. A joint statement from four human rights organizations, including Amnesty International, called the criminal proceedings against Buzs-Hbel a turning point for the European Union. For the first time in EU history, a person is facing criminal charges for organising a Pride march: an act protected under the EU Charter of Fundamental Rights (the Charter), the European Convention on Human Rights (ECHR), and the values defined in Article 2 TEU, the groups stated. If criminal law can be used in an EU Member State to punish someone for organising Pride, the precedent will embolden others to follow. It marks the first breach of the EUs internal firewall against authoritarian legalism the point where Russian-style repression enters the Unions own legal space.The groups warned that the credibility of the European Union is at stake. A gay Roma teacher in southern Hungary should not have to risk going to prison to remind the EU what its values mean. Whether Europe acts now to defend him and the values he stands for will determine whether those values still protect anyone at all. Buzs-Hbelechoed similar sentiments while speaking to The Guardian, explaining that the case isnt really about him. In the eyes of those in power, I am just a speck of dust, he said. This is directed at my broader community, and the goal is to intimidate the people around me. They are using me as a tool to set an example for the entire country.Subscribe to theLGBTQ Nation newsletterand be the first to know about the latest headlines shaping LGBTQ+ communities worldwide.

Former Transportation Secretary Pete Buttigieg does not agree with President Donald Trumps claim that the economy has not faced any problems since he took office.The word affordability I inherited a mess, Trump told Politicos Dasha Burns yesterday. Prices were at an all-time high when I came in; prices are coming down substantially. Related A disgrace: Pete Buttigieg blasts Trump for trying to send an Afghan refugee back to the Taliban When asked how he would grade the economy, Trump said, A-plus-plus-plus-plus-plus-plus. He cited prices going down since he became president as his reasoning for the grade, even though prices have continued to increase since he took office, and the rate at which they increased (inflation) remains above the Federal Reserve Banks target.This is the economy that Donald Trump called A++++++ today, Buttigieg responded on social media, sharing headlines about increasing prices and layoffs. One of the headlines he shared was about a report from the consulting firm Challenger, Gray & Christmas that found that layoff announcements this year are at their highest level since 2020, the last year that Trump was president.This is the economy that Donald Trump called "A++++++" today. Pete Buttigieg (@petebuttigieg.bsky.social) 2025-12-10T00:52:08.792Z

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03950-4From lectures by avatars to entire qualifications, higher education centred around AI is just around the corner.

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03951-3Nimble, responsive and collaborative, these institutions stand out in the Nature Index.

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03941-5New models, efforts for early detection and better therapies may help change pancreatic cancers aggressive course.

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03949-xWhy some institutions are betting on technology to stay relevant.

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03952-2A description of the terminology and methodology used in this supplement, and a guide to the functionality that is available free online at natureindex.com.

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President Donald Trump speaks at the Mount Airy Casino Resort in Mount Pocono, Pa., Tuesday, Dec. 9, 2025. (AP Photo/Matt Rourke)2025-12-10T16:25:42Z WASHINGTON (AP) As he shook President Barack Obamas hand and pulled him in for what he thought was a private aside, Vice President Joe Biden delivered an explicit message: This is a big f deal. The remark, overheard on live microphones at a 2010 ceremony for the Affordable Care Act, caused a sensation because open profanity from a national leader was unusual at the time.More than 15 years later, vulgarity is now in vogue.During a political rally Tuesday night in Pennsylvania that was intended to focus on tackling inflation, President Donald Trump used profanity at least four times. At one point, he even admitted to disparaging Haiti and African nations as shithole countries during a private 2018 meeting, a comment he denied at the time. And before a bank of cameras during a lengthy Cabinet meeting last week, the Republican president referred to alleged drug smugglers as sons of b-s. While the Biden incident was accidental, the frequency, sharpness and public nature of Trumps comments are intentional. They build on his project to combat what he sees as pervasive political correctness. Leaders in both parties are seemingly in a race now to the verbal gutter. Vice President JD Vance called a podcast host a dipst in September. In Thanksgiving remarks before troops, Vance joked that anyone who said they liked turkey was full of s-. After one National Guard member was killed in a shooting in Washington last month and a second was critically injured, top Trump aide Steven Cheung told a reporter on social media to shut the f- up when she wrote that the deployment of troops in the nations capital was for political show. Among Democrats, former Vice President Kamala Harris earned a roar of approval from her audience in September when she condemned the Trump administration by saying these mother- are crazy. After Trump called for the execution of several Democratic members of Congress last month, Sen. Chris Murphy, D-Conn., said it was time for people with influence to pick a f side. Senate Democratic leader Chuck Schumer of New York said the administration cannot f- around with the release of the Jeffrey Epstein files. Democratic Rep. Jasmine Crockett, who on Monday announced her Senate campaign in Texas, did not hold back earlier this year when asked what she would tell Elon Musk if given the chance: F- off. The volley of vulgarities underscore an ever-coarsening political environment that often plays out on social media or other digital platforms where the posts or video clips that evoke the strongest emotions are rewarded with the most engagement. If you want to be angry at someone, be angry at the social media companies, Utah Gov. Spencer Cox, a Republican, said Tuesday night at Washington National Cathedral, where he spoke at an event focused on political civility. Its not a fair fight. Theyve hijacked our brains. They understand these dopamine hits. Outrage sells.Cox, whose national profile rose after calling for civility in the wake of conservative activist Charlie Kirks assassination in his state, approved an overhaul of social media laws meant to protect children. A federal judge has temporarily blocked the state law. Tough political talk is nothing newTough talk is nothing new in politics, but leaders long avoided flaunting it.Recordings from Democrat Lyndon B. Johnsons administration, for instance, revealed a crude, profane side of his personality that was largely kept private. Republican Richard Nixon bemoaned the fact that the foul language he used in the Oval Office was captured on tape. Since neither I nor most other Presidents had ever used profanity in public, millions were shocked, Nixon wrote in his book In the Arena.Politicians have always sworn, just behind closed doors, said Benjamin Bergen, a professor at the University of California-San Diegos Department of Cognitive Science and the author of What the F: What swearing reveals about our language, our brains, and ourselves. The big change is in the past 10 years or so, its been much more public. As both parties prepare for the 2026 midterm elections and the 2028 presidential campaign, the question is whether this language will become increasingly mainstream. Republicans who simply try to imitate Trumps brash style do not always succeed with voters. Democrats who turn to vulgarities risk appearing inauthentic if their words feel forced. For some, it is just a distraction.Its not necessary, said GOP Rep. Don Bacon of Nebraska, who is retiring next year after winning five elections in one of the most competitive House districts. If thats what it takes to get your point across, youre not a good communicator. There are risks of overusing profanityThere also is a risk that if such language becomes overused, its utility as a way to shock and connect with audiences could be dulled. Comedian Jerry Seinfeld has talked about this problem, noting that he used swear words in his early routines but dropped them as his career progressed because he felt profanity yielded only cheap laughs. I felt like well I just got a laugh because I said f- in there, he said in a 2020 interview on the WTF podcast with fellow comedian Marc Maron. You didnt find the gold. White House spokesperson Liz Huston said Trump doesnt care about being politically correct, he cares about Making America Great Again. The American people love how authentic, transparent, and effective the President is.But for Trump, the words that have generated the most controversy are often less centered in traditional profanity than slurs that can be interpreted as hurtful. The final weeks of his 2016 campaign were rocked when a tape emerged of him discussing grabbing women by their genitals, language he minimized as locker room talk. His shithole remark in 2018 was widely condemned as racist.More recently, Trump called a female journalist piggy, comments that his press secretary, Karoline Leavitt, defended as evidence of a president who is very frank and honest. Trumps use of a slur about disabled people prompted an Indiana Republican whose child has Down syndrome to come out in opposition to the presidents push to redraw the states congressional districts. On rare occasions, politicians express contrition for their choice of words. In an interview with The Atlantic published last week, Gov. Josh Shapiro, D-Pa., dismissed Harris depiction of him in her book about last years presidential campaign by saying she was trying to sell books and cover her a. He seemed to catch himself quickly. I shouldnt say cover her a, he said. I think thats not appropriate.

Many are voicing alarm over a long, rambling post by Donald Trump on Truth Social in which he admitted to taking multiple cognitive tests while surrounded by doctors and also called it treasonous to question his health.I go out of my way to do long, thorough, and very boring Medical Examinations at the Great Walter Reed National Military Medical Center, seen and supervised by top doctors, all of whom have given me PERFECT Marks Some have even said they have never seen such Strong Results, he wrote. Related Trump deadnames history-making transgender admiral on her official government portrait I do these Tests because I owe it to our Country. In addition to the Medical, I have done something that no other President has done, on three separate occasions, the last one being recently, by taking what is known as a Cognitive Examination, something which few people would be able to do very well, including those working at The New York Times, and I ACED all three of them in front of large numbers of doctors and experts, most of whom I do not know. I have been told that few people have been able to ace this Examination and, in fact, most do very poorly, which is why many other Presidents have decided not to take it at all. He then called out the New York Times as true Enemies of the People for questioning his physical and mental health, calling it seditious, perhaps even treasonous. Insights for the LGBTQ+ community Subscribe to our briefing for insights into how politics impacts the LGBTQ+ community and more. Subscribe to our Newsletter today The rest of the post, he spent mostly praising himself as the smartest, best president in history.Many on social media have been weighing in. Wonder what kind of conversation wed be having if everyone in America were forced to read every word of this post out loud, all the way through pic.twitter.com/G2vrxLI8tD Roger Sollenberger (@SollenbergerRC) December 10, 2025This pretty much confirms Trump is having serious health problems. The first part of the tweet is a feint. The main purpose was to counter the rumors of his failing health. And mentioning that he had to go for three cognitive tests? What healthy senior has to go for three pic.twitter.com/TQF7Chgfg7 John Aravosis (@aravosis) December 10, 2025If anyone else wrote something like this, it would be universally acknowledged that the person is mentally unstable. pic.twitter.com/4QWTGME957 Justin Amash (@justinamash) December 10, 2025Donald Trump is in poor physical health. https://t.co/OT3wd1QfBg Gavin Newsom (@GavinNewsom) December 10, 2025This mf is such a joke I cant believe this is real life. What did we do to deserve this idiocy the-michael-datson.bsky.social (@fuller_sean) December 10, 2025 Subscribe to theLGBTQ Nation newsletterand be the first to know about the latest headlines shaping LGBTQ+ communities worldwide.

Nico Greetham is ending the year with some thirst.The handsome queer actor is known for his adorable roles in Love, Victor and American Horror Story, but the star is also known for spicing up social media with some steamy thirst traps.As the year comes to a close, Greetham posted a sweaty new shirtless pic working out in the gym and fans went berserk online. Check out the highlights below! (@) (@) (@) (@) (@) (@) (@) (@)

Jen Shah has been released from federal custody, closing a chapter that reshaped both her public image and her place in the Real Housewives universe.The former Real Housewives of Salt Lake City cast member was released early Wednesday, Dec. 10, after serving nearly three years in prison for her role in a nationwide telemarketing fraud scheme. Shah, 52, exited the Federal Prison Camp in Bryan, Texas, where she had been incarcerated since Feb. 17, 2023, according to confirmation provided to PEOPLE.Transitioning Out of Federal CustodyFollowing her departure from FPC Bryan, Shah was transferred to community confinement overseen by the Bureau of Prisons Phoenix Residential Reentry Management Office. Under Bureau of Prisons policy, that placement can include home confinement or time at a residential reentry center, often referred to as a halfway house.We can confirm that Jennifer Shah transferred on December 10, 2025, from the Federal Prison Camp (FPC) Bryan to community confinement overseen by the Bureau of Prisons (BOP) Phoenix Residential Reentry Management (RRM) Office, a BOP spokesperson told PEOPLE. Community confinement means the inmate is in either home confinement or a Residential Reentry Center (RRC, or halfway house). For privacy, safety, and security reasons, we do not disclose an individuals specific location while in community confinement.Officials declined to share additional details regarding Shahs next steps, citing standard privacy protocols.From Arrest to SentencingShah was arrested in March 2021 alongside her assistant, Stuart Smith, after federal investigators alleged the pair participated in a telemarketing operation that targeted thousands of victims, including elderly individuals. Prosecutors charged Shah with conspiracy to commit wire fraud related to telemarketing and conspiracy to commit money laundering.In July 2022, Shah pleaded guilty to wire fraud conspiracy.I am sorry. My actions have hurt innocent people, Shah said during her sentencing on Jan. 6, 2023. I want to apologize by saying, I am doing all I can to earn the funds to pay restitution.She was sentenced to six-and-a-half years in prison and ordered to pay $6.5 million in restitution before surrendering to federal authorities the following month.Sentence Reductions and Early ReleaseAlthough Shah initially faced more than six years behind bars, her sentence was reduced several times. The Bureau of Prisons attributed the reductions to good conduct, participation in institutional programming and progress toward financial restitution.One month into her sentence, Shah received a one-year reduction. Additional adjustments in October 2024 and January 2025 shifted her projected release date into late 2026. Another reduction in August moved that date up again. In mid-November, it was reported that the Bureau of Prisons approved her release for Dec. 10.He added, Jens in a really positive, hopeful place mentally. Shes done a lot of reflecting and real growth during her time away, and is genuinely not the same woman as she was before.Family, Faith, and ReflectionThroughout Shahs incarceration, her husband, University of Utah football coach Sharrieff Coach Shah, remained publicly supportive. The couple share two sons, Sharrieff Jr., 31, and Omar, 22.In a February 2024 letter written from prison, Shah described the emotional toll of separation from her family while reflecting on personal changes shaped by her time behind bars. She wrote that faith, daily prayer and therapy had helped her navigate moments of despair and offered perspective through connections with other incarcerated women.I am most grateful for the aspects of my life that have never left me: my family and faith, Shah wrote. In my daily prayers, I ask God for the courage to realize I am worthy of a second chance.While Shahs legal obligations remain ongoing, her release signals a major shift, one that brings her back into public view, albeit under supervision, and far from the glamorous persona that once defined her reality TV tenure.Source

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09854-7Comprehensive large-scale studies of multi-national populations identified microbiome species consistently associated with favourable and unfavourable health markers, informing future studies of the human gut microbiome and its association with diet and cardiometabolic conditions.

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03945-1The disease is often caught too late to affect a persons prognosis scientists are looking to change that.

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09866-3Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03577-5The genetic engineering of mosquitoes offers a potentially transformative, self-sustaining opportunity for malaria control and elimination in Africa. By rendering mosquitoes unable to transmit the malaria parasite, even when they bite humans, the technology provides a mosquito-based intervention to complement existing efforts.

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09685-6Engineering of local Anopheles gambiae under containment enables the generation of a transgenic strain equipped with non-autonomous gene drive capabilities that robustly inhibits genetically diverse Plasmodium falciparum isolates obtained from naturally infected children.

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Elon Musk attends the Saudi Investment Forum at the Kennedy Center, Wednesday, Nov. 19, 2025, in Washington. (AP Photo/Evan Vucci)2025-12-10T17:14:01Z Mega billionaire Elon Musk, in a friendly interview with his aide and conservative influencer Katie Miller, said his efforts leading the Department of Government Efficiency were only somewhat successful and he would not do it over again. The Tesla and SpaceX CEO, who also owns the social media platform X, still broadly defended President Donald Trumps controversial pop-up agency that Musk left in the spring before it shuttered officially last month. Yet Musk bemoaned how difficult it is to remake the federal government quickly, and he acknowledged how much his businesses suffered because of his DOGE work and its lack of popularity.We were a little bit successful. We were somewhat successful, he told Miller, who once worked as a DOGE spokeswoman charged with selling the agencys work to the public.When Miller pressed Musk on whether he would do it all over again, he said: I dont think so. ... Instead of doing DOGE, I would have, basically, built ... worked on my companies. Almost wistfully, Musk added, They wouldnt have been burning the cars a reference to consumer protests against Tesla. Still, things certainly have turned up for Musk since his departure from Trumps administration. Tesla shareholders approved a pay package that could make Musk the worlds first trillionaire.Musk was speaking as a guest on the Katie Miller Podcast, which Miller, who is married to top Trump adviser Stephen Miller, launched after leaving government employment to work for Musk in the private sector. The two sat in chairs facing each other for a conversation that lasted more than 50 minutes and spanned topics from DOGE to Musks thoughts on AI, social media, conspiracy theories and fashion. Miller did not press Musk on the innerworkings of DOGE and the controversial manner in which it took over federal agencies and data systems. Musk credited the agency with saving as much as $200 billion annually in zombie payments that he said can be avoided with better automated systems and coding for federal payouts. But that number is dwarfed by Musks ambitious promises at one time that an efficiency commission could measure savings in the trillions. BILL BARROW Barrow covers U.S. politics for The Associated Press. He is based in Atlanta. twitter mailto

As the year comes to a close, people may be evaluating whether they reached their personal goals, but Pornhub is looking back at what made us all horny in 2025. And the stats are spicy!Last year, the wild analytics showed us that twink was the most popular LGBTQ+ term of the year, but this year, twink got bumped from that No. 1 spot and femboy rose to the top!Queer people were also busy searching for anime, pinot, furry, and straight guys first time. Twink may have moved down to second place when it came to search terms, but it still topped the ranking of the Most Viewed Gay Categories on the site, alongside big dick, bareback, black, and group.Of course, everyone had their fave gay porn stars they couldnt stop searching for. Tyler Wu, Malik Delgaty, Sandro Jenner, Rhyheim Shabazz, and Jkab Ethan Dale topped the list year.Transphobia may be on the rise among Republicans, but when it comes to what makes us horny, searches for trans in different Pornhub categories are on the rise. And trans porn stars Emma Rose, Eva Maxim, Ariel Demure, SissyMilana, and PuppygirlXO were the most viewed in 2025.Emma RoseSee on InstagramThese performers and spicy search terms may have led the way for LGBTQ+ adult content, but lesbian and transgender also topped the charts for everyones Most Viewed Categories of 2025. Pornhub also breaks down Top Relative Searches by state, and the results are fascinating. Besides outliers like Oregon apparently loving horny grandma porn, Minnesota has a thing for anal beads, Illinois is obsessed with hairy armpits, and Vermont is all about jockstraps. We see you, Vermont!To see the full list of Pornhubs 2025 stats, head to the official website here.

Fashions most watched night is setting the tone early, and the 2026 Met Gala is already shaping up to be historic. Vogue confirmed that Beyonc, Nicole Kidman and Venus Williams will join Anna Wintour as co-chairs for next years gala, marking a rare all-female leadership lineup for the event.Wintour, the longtime editor-in-chief of Vogue and global director of Cond Nast, remains the constant presence guiding the annual fundraiser for the Metropolitan Museum of Arts Costume Institute. The addition of three icons from music, film and sports signals a broadened vision for the gala, one rooted in cultural influence far beyond fashion alone.Beyoncs Long-Awaited ReturnAmong the announcements, Beyoncs involvement carries particular weight. The Grammy-winning artist has not appeared on the Met steps in ten years. Her most recent attendance came in 2016 during the Manus x Machina gala, where she arrived in Givenchy Haute Couture and promptly set the internet ablaze.Since then, Beyonc has carefully curated her public appearances, choosing moments that align with her artistic eras. Her return as a co-chair, not just an attendee, suggests something intentionally timed. With her genre-bending album Cowboy Carter still shaping pop culture conversations, anticipation around her 2026 look is already at a fever pitch.Familiar Faces With Fashion PedigreeNicole Kidman and Venus Williams bring their own Met Gala histories to the table. Kidman has become a reliable presence at the event, known for embracing narrative-driven fashion choices that lean theatrical without tipping into costume. Williams, meanwhile, continues to bridge athletic excellence with design, often highlighting craftsmanship and movement in her red-carpet appearances.Both women attended the 2025 Met Gala, themed Superfine: Tailoring Black Style, and have long-standing relationships with fashion houses and designers who prioritize innovation.A Shift in Leadership EnergyThe announcement also marks a tonal pivot from the previous year. The 2025 gala featured an all-male group of co-hosts, Colman Domingo, Lewis Hamilton, A$AP Rocky and Pharrell Williams, each of whom interpreted tailoring through individual lenses.Next years trio brings a different dynamic, one likely to explore fashion as lived experience rather than spectacle alone. That perspective aligns cleanly with the 2026 theme.Inside the Costume Art ThemeThe upcoming exhibition, titled Costume Art, will examine the body as both subject and medium. According to curator Andrew Bolton, the focus moves away from viewing clothing purely as visual design and instead frames fashion as an art form shaped by wear, movement and physical presence.Costume Art will also mark the debut of the Mets newly opened Cond M. Nast Galleries, making it a milestone moment for the museum itself. The exhibition is set to feature both historical and contemporary pieces, grouped by concepts such as the Naked Body, the Pregnant Body and the Aging Body.Bolton explained that clothing serves as a connective tissue throughout the museum, linking disciplines that might otherwise remain siloed. Fashion, in this framing, becomes universal, experienced by every visitor, regardless of background.Looking Ahead to the First Monday in MayWith nearly a year to go, designers, stylists and celebrities are already beginning the quiet work of interpretation. While the final looks remain under wraps, the presence of Beyonc, Kidman and Williams suggests a 2026 gala that prioritizes intention over excess.Until then, fashion fans can revisit the defining outfits of the 2025 Met Gala, a reminder that the red carpet isnt just about clothing, but storytelling.Before the 2026 looks make their debut, lets take a moment to relive some of the show-stopping outfits that defined this years Met Gala.Source

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09821-2A forward genetic screen in Caenorhabditis elegans reveals that decreased levels of the ferredoxin FDX2 suppress the loss of frataxin in worms and in mice by relief of FDX2 inhibition of frataxin-stimulated NFS1 activity.

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03732-yThe emission of photons by excited nuclei has been explored for timekeeping and sensing, but nuclear processes that eject electrons offer practical advantages.