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Nature, Published online: 07 July 2025; doi:10.1038/d41586-025-02096-7Experimental treatment could offer a safer, cheaper alternative to CAR T cell therapies for disorders such as lupus.

Nature, Published online: 07 July 2025; doi:10.1038/d41586-025-02075-yAward-winning mentors share best practice to keep your team going amid political upheavals, economic downturns and other events.

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President Trump said nations that support the groups Anti-American policies would face an additional 10 percent tariff. He did not elaborate.

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For someone who says she is fighting AI bot scrapers just in her free time, Xe Iaso seems to be putting up an impressive fight. Since she launched it in January, Anubis, a program is designed to help protect the small internet from the endless storm of requests that flood in from AI companies, has been downloaded nearly 200,000 times, and is being used by notable organizations including GNOME, the popular open-source desktop environment for Linux, FFmpeg, the open-source software project for handling video and other media, and UNESCO, the United Nations organization for educations, science, and culture.Iaso decided to develop Anubis after discovering that her own Git server was struggling with AI scrapers, bots that crawl the web hoovering up anything that can be used for the training data that power AI models. Like many libraries, archives, and other small organizations, Iaso discovered her Git server was getting slammed only when it stopped working.I wasn't able to load it in my browser. I thought, huh, that's strange, Iaso told me on a call. So I looked at the logs and I figured out that it's restarted about 500 times in the last two days. So I looked in the access logs and I saw that [an] Amazon [bot] was clicking on every single link.Iaso knew it was an Amazon bot because it self identified as such. She said she considered withdrawing the Git server from the open web but that because she wants to keep some of the source code hosted there open to the public, she tried to stop the Amazon bot instead.I tried some things that I cant admit in a recorded environment. None of them worked. So I had a bad idea, she said. I implemented some code. I put it up on GitHub in an experimental project dumping ground, and then the GNOME desktop environment started using it as a Hail Mary. And that's about when I knew that I had something on my hands.There are several ways people and organizations are trying to stop bots at the moment. Historically, robots.txt, a file sites could use to tell automated tools not to scrape, was a respected and sufficient norm for this purpose, but since the generative AI boom, major AI companies as well as less established companies and even individuals, often ignored it. CAPTCHAs, the little tests users take to prove theyre not a robot, arent great, Iaso said, because some AI bot scrapers have CAPTCHA solvers built in. Some developers have created infinite mazes that send AI bot scrapers from useless link to useless link, diverting them from the actual sites humans use and wasting their time. Cloudflare, the ubiquitous internet infrastructure company, has created a similar AI labyrinth feature to trap bots.Iaso, who said she deals with some generative AI at her day job, told me that from what I have learned, poisoning datasets doesn't work. It makes you feel good, but it ends up using more compute than you end up saving. I don't know the polite way to say this, but if you piss in an ocean, the ocean does not turn into piss.In other words, Iaso thinks that it might be fun to mess with the AI bots that are trying to mess with the internet, but in many cases its not practical to send them on these wild goose chases because it requires resources Cloudflare might have, but small organizations and individuals dont.Anubis is an uncaptcha, Iaso explains on her site. It uses features of your browser to automate a lot of the work that a CAPTCHA would, and right now the main implementation is by having it run a bunch of cryptographic math with JavaScript to prove that you can run JavaScript in a way that can be validated on the server.Essentially, Anubis verifies that any visitor to a site is a human using a browser as opposed to a bot. One of the ways it does this is by making the browser do a type of cryptographic math with JavaScript or other subtle checks thatbrowsers do by default but bots have to be explicitly programmed to do. This check is invisible to the user, and most browsers since 2022 are able to complete this test. In theory, bot scrapers could pretend to be users with browsers as well, but the additional computational cost of doing so on the scale of scraping the entire internet would be huge. This way, Anubis creates a computational cost that is prohibitively expensive for AI scrapers that are hitting millions and millions of sites, but marginal for an individual user who is just using the internet like a human.Anubis is free, open source, lightweight, can be self-hosted, and can be implemented almost anywhere. It also appears to be a pretty good solution for what weve repeatedly reported is a widespread problem across the internet, which helps explain its popularity. But Iaso is still putting a lot of work into improving it and adding features. She told me shes working on a non cryptographic challenge so it taxes users CPUs less, and also thinking about a version that doesnt require JavaScript, which some privacy-minded disable in their browsers.The biggest challenge in developing Anubis, Iaso said, is finding the balance.The balance between figuring out how to block things without people being blocked, without affecting too many people with false positives, she said. And also making sure that the people running the bots can't figure out what pattern they're hitting, while also letting people that are caught in the web be able to figure out what pattern they're hitting, so that they can contact the organization and get help. So that's like, you know, the standard, impossible scenario.Iaso has a Patreon and is also supported by sponsors on Github who use Anubis, but she said she still doesnt have enough financial support to develop it full time. She said that if she had the funding, shed also hire one of the main contributors to the project. Ultimately, Anubis will always need more work because it is a never ending cat and mouse game between AI bot scrapers and the people trying to stop them.Iaso said she thinks AI companies follow her work, and that if they really want to stop her and Anubis they just need to distract her.If you are working at an AI company, here's how you can sabotage Anubis development as easily and quickly as possible, she wrote on her site. So first is quit your job, second is work for Square Enix, and third is make absolute banger stuff for Final Fantasy XIV. Thats how you can sabotage this the best.

Despite the medias breathless speculation, there was never any doubt that Republican senators would sign off on the Senate version of the inaptly named One Big Beautiful Bill. When it comes to Donald Trump, Republicans always fall in line, even at the expense of the nation and their own future.Giving the rich tax breaks has been a core GOP principle for decades, so that was easy. The hard part was ripping away the safety net for millions of Americans, many of them in GOP districts, while blowing a giant hole in the nations deficit. Ultimately, that didnt matter. Republicans had to agree to live in Trumps alternate reality, where nothing bad happens as a result of his actions. Related Last weeks Supreme Court rulings show just how fragile marriage equality may be The right-wing of the Court continues to disregard precedent and place the rights of conservative Christians above everyone elses. In a nod to the damage that the law will cause, Republicansfront-loaded the tax breaks and back-loaded the safety net cuts. In particular, Republicans made sure to push the work requirement for Medicaid until after the midterm elections next year. The paperwork is likely to be so onerous having to prove your eligibility every six months that as many as 17 million people are likely to lose health care coverage over the coming years. Dive deeper every day Join our newsletter for thought-provoking commentary that goes beyond the surface of LGBTQ+ issues Subscribe to our Newsletter today Perhaps the most frightening part of the new law is that it creates a new private army out of ICE. The law would allocate $75 billion more to ICE through 2029. Of that, $8 billion (which is what its current baseline budget is) would be to hire additional personnel. Another $45 billion would be for detention centers. By comparison, the entire federal prison budget is $8.3 billion per year.I dont think anyone is prepared for what they just did with ICE,Rep. Alexandria Ocasio-Cortez (D-NY) said. This is not a simple budget increase. It is an explosionmaking ICE bigger than the FBI, U.S. Bureau of Prisons, DEA, & others combined.To put this in perspective: the increase would have paid for the HIV vaccine program that Trump killed for savings nearly 400 times over. Given the penchant of ICE agents to look and act more like kidnappers than law enforcement officers, as well as their willingness to rough up elected officials, the idea of turbocharging the agency is disturbing. Thats especially true since Trump has been talking about deporting American citizens. Ostensibly and still completely illegally Trump is talking about deporting citizens who commit crimes, but he used that same rhetoric about immigrants during the campaign, and his deportation effort is about going after people who are following the laws as well. ICE would be the perfect mechanism for testing how far Trump can go with his authoritarian inclinations. Having failed to capitalize on the widespread public dislike for the new law while it was still a bill in Congress, Democrats are now excited about running against the ruin that it will cause. But Democrats are still engaged in an endless round of navel-gazing about last years election and havent figured out how to run for something and not just against something. The idea that the law will prove so unpopular that it will propel Democrats to victory in the House and Senate next year is a pleasant wish, but with so much at stake in the intervening 16 months, thats a long wait for an uncertain event. As a reminder, Trump is pretty unpopular, too, and hes been elected twice.Meanwhile, things will only get worse as Trump and the GOP continue to tear apart the norms of democracy and its protections. Already, the conservatives on the Supreme Court, the handmaidens of Project 2025, have a major case for next term that will likely build on their anti-trans rulings. The One Big Beautiful Bill will produce shockwaves for the worse throughout the nation for years to come. But those shockwaves have been underway since the day that Trump took office last January.Subscribe to theLGBTQ Nation newsletterand be the first to know about the latest headlines shaping LGBTQ+ communities worldwide.

Nature, Published online: 07 July 2025; doi:10.1038/d41586-025-02072-1Risto Taipale works on the maintenance of a research station that provides publicly accessible data on climate change.

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CANYON LAKE, TXRemarking that the 3-year-old didnt even come close to stealing the show at a recent family wedding, witnesses reported Monday that they were unimpressed when a completely charmless flower girl walked directly down the aisle. Sure, she did her job, but she utterly failed to delight us with any adorable toddling, spinning, or other childlike antics that would have really made her shine, said guest Jackie Pearlman, noting that the entire audience watched stone-faced as the child calmly completed her assigned task instead of accidentally dropping her bouquet, nervously sucking her thumb, or giggling uncontrollably as she sprinted wildly around from pew to pew. Its unfortunate, because there were so many opportunities where she could have wandered around confused, stubbornly refused to wear her veil, or even tripped, fallen flat on her face, and burst out crying. Overall, there was nothing that made me want to crane my head around and gently chuckle. Not a fan. Pearlman added that the flower girl was nothing compared to the completely charmless groom, who totally failed to show up drunk.The post Completely Charmless Flower Girl Walks Directly Down Aisle appeared first on The Onion.

LOS ANGELESAttributing her behavior to insecurity about the government, local woman Kirsten Sears told reporters Monday that she did not like eating in front of the surveillance state. I try to remember the government is more interested in my ideology than my macronutrients, but still, every time, I get so embarrassed, said Sears, who explained that she had developed the fear in adolescence around the time she started becoming self-conscious about her personal data and growing digital footprint. Id hate for Big Brother to see me with mustard on my face. Usually around lunch Ill head to a stairwell, look around and realize thats not safe, hop in my car, drive 150 miles to the desert, get out, and then walk 10 more miles by foot. I know its irrational, but I cant stop imagining that every time I take a bite of my sandwich, Peter Thiel is thinking, Oink, oink. At press time, Sears added that she restricted herself to neutral-colored foods to avoid satellite detection.The post Insecure Woman Doesnt Like Eating In Front Of Surveillance State appeared first on The Onion.

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The attorney general of Idaho issued an opinion telling schools not to allow teachers to post signs that say Everyone is Welcome Here, claiming that the message that public education is for everyone regardless of race, gender, sexual orientation, or other categories is Democratic in nature and therefore illegally partisan.These signs are part of an ideological/social movement which started in Twin Cities, Minnesota, following the 2016 election, Idaho Attorney General Ral Labrador (R) said in guidance issued to a school. Since that time, the signs have been used by the Democratic party as a political statement. Related GOP law forces library to require ID from patrons under 30 to access adult books The adult book section includes books with queer themes, something a new law defines as sexual content. Labrador also noted that the state Democratic Party is selling signs that say Everyone is Welcome Here, but state Democrats say that they only started selling those signs at cost in order to draw attention to conservatives early attempts to ban them. Never Miss a Beat Subscribe to our newsletter to stay ahead of the latest LGBTQ+ political news and insights. Subscribe to our Newsletter today The conflict centers on Idahos H.B. 41, which took effect last week and bans school employees from displaying flags or banners that show opinions, emotions, beliefs or thoughts about politics, economics, society, faith or religion.Earlier this year, the states West Ada School District banned Sarah Inama, a teacher at Lewis and Clark Middle School, from displaying a sign that says, Everyone is Welcome Here. It showed a drawing of peoples hands with different skin tones, each with a heart on it.The district also ordered her to take down another sign that read, In this room everyone is welcome, important, accepted, respected, encouraged, valued, equal on top of a background of rainbow colors. The rainbow colors included seven stripes, which differs from the six-striped rainbow Pride flag. "I was told that 'everyone is welcome here' is not something that everybody believes. So that's what makes it a personal opinion," Inama said, attributing these statements to building administration and district personnel."https://t.co/ZBbN2ZO0wx Concerned Citizen (@CyDogood) March 13, 2025The controversy over the signs garnered national headlines in March, and the state attorney generals office looked into how the law would apply in such cases, issuing an opinion last week. The attorney general determined that these specific signs would violate H.B. 41 and claimed that the statements in the signs are part of a political movement and not, as defenders of the signs argued, generally agreed-upon beliefs about the nature of public education.Labradors guidance hyperlinked a 2017 news story about a group of women who protested racist graffiti that appeared at a local high school the day after the president was elected to his first term, according to the Idaho Capital-Sun, which posted the attorney generals opinion. The women carried signs that read, All are Welcome Here.The guidance then claimed that Inama started posting the Everyone is Welcome Here sign in 2017, during the height of the above-referenced social movement.In March, Inama disagreed that the message is political or partisan.I dont agree. I dont agree that this is a personal opinion, she told KTVB at the time. I feel like this is the basis of public education.Inama resigned in May.Subscribe to theLGBTQ Nation newsletterand be the first to know about the latest headlines shaping LGBTQ+ communities worldwide.

Nature, Published online: 07 July 2025; doi:10.1038/s41586-025-08909-zAuthor Correction: Adipose tissue retains an epigenetic memory of obesity after weight loss

U.S. coach Mauricio Pochettino was fuming after the VAR didn't penalize Mexico. Did he have a point?

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A three-judge appellate panel has ruled that a transgender teacher cannot use she/her pronouns in the classroom. The 11th Circuit Court of Appeals made the 2-1 decision in accordance with Floridas Dont Say Gay law, with the majority claiming that the plaintiff, high school algebra teacher Katie Wood, hasnt shown a substantial likelihood that the law violates her right to free speech. Related Supreme Court just threw out four pro-trans rulings The justices ordered appellate courts to review cases involving gender-affirming care coverage and birth certificates. The opinion was written by U.S. Circuit Judge Kevin Newsom and signed off on by Judge Andrew Brasher, both of whom were appointed by the current president. It overturns a preliminary injunction issued in 2024 by U.S. District Judge Mark Walker a Barack Obama appointee and remands the case back to the district court. Never Miss a Beat Subscribe to our newsletter to stay ahead of the latest LGBTQ+ political news and insights. Subscribe to our Newsletter today The appellate decision asserted that a teachers right to speak is not without limits because, as public employees, they speak in part on behalf of the government. The decision said Wood cannot show that she was speaking as a private citizen rather than a government employee. U.S. Circuit Judge Adalberto Jordan, also an Obama appointee, dissented. Florida, however, has recently come to believe that the First Amendment does not prevent it from dictating what can and cannot be said, he wrote, adding that Wood has substantially demonstrated that her use of her preferred personal title and pronouns constitutes private speech on a matter of public concern rather than government speech.Wood sued the state after Florida passed HB 1069, which states that an employee or contractor of a public K-12 educational institution may not provide to a student his or her preferred personal title or pronouns if such preferred personal title or pronouns do not correspond to his or her sex. Violations of the law are punishable by termination and even suspension or revocation of a teaching certificate. After the law passed, Wood was told by the schools principal that she could no longer refer to herself as Miss, even though she had legally changed her name and gender markers on her government-issued documents and gone by Ms. Wood for four years. In his issuance of a preliminary injunction, Judge Walker declared, Once again, the State of Florida has a First Amendment problem. This time, the State of Florida declares that it has the absolute authority to redefine your identity if you choose to teach in a public school. So, the question before this Court is whether the First Amendment permits the State to dictate, without limitation, how public-school teachers refer to themselves when communicating to students. The answer is a thunderous no.Ours is a Union of individuals, he added, celebrating ourselves and singing ourselves and being ourselves without apology.The injunction applied specifically to Wood rather than all trans teachers in the state, as does the appellate courts decision to overturn it.Subscribe to theLGBTQ Nation newsletterand be the first to know about the latest headlines shaping LGBTQ+ communities worldwide.

Travelling fans in Switzerland for Euro 2025 will notice a football-themed twist to the city as a green woman kicking a ball takes over the traffic lights.

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It has been said that the first Pride was a riot, sparked by the Stonewall Uprising in 1969. The meaning of Pride Month has expanded and evolved since Stonewall and the subsequent first Pride Parade in 1970. Though Pride was established before the rise of HIV and AIDS, HIV awareness and advocacy have stood at the center of Pride since the early days of the illness.Though HIV is no longer the death sentence it once was, there are still approximately 1.2 million people living with HIV in the United States and over 30,000 new infections every year. The continued prevalence of HIV means that HIV education and advocacy still play an important role in Pride Month. Related FDA approves twice-a-year HIV prevention drug that could help end the virus worldwide It reduces transmissions by up to 96%, but now world governments and big-dollar funders will need to step in. Pride Month presents an opportunity to spotlight advancements made in HIV prevention and treatment. It also gives advocates a chance to take the world stage and be heard, letting people know that HIV is still a factor in the lives of many, especially those within the LGBTQ+ community. Pride is a time to remember the fight for equality, to celebrate living authentically, and to deepen bonds within the community. It can also be a time for promoting testing, educating the public, and keeping the fight to end HIV alive. Dive deeper every day Join our newsletter for thought-provoking commentary that goes beyond the surface of LGBTQ+ issues Subscribe to our Newsletter today Deepening the meaning of PrideSince its inception, Pride has grown year by year into a worldwide celebration. During the height of the HIV/AIDS epidemic in the mid-1980s through the early 1990s, Pride celebrations were intermingled with protests and rallies advocating for more attention to prevention and care for those living with HIV and AIDS. Activists pushed for government intervention at a time when many government officials refused to say the word AIDS and the spectre of the disease and the neglect of people living with it overshadowed much of the Pride movement for well over a decade.Today, while Pride Month remains focused on justice and equality for the LGBTQ+ community, HIV advocacy should still take a front seat. This is particularly true in the South, which carries a disproportionate burden of HIV infections.Regional statistics mixed with a persistent stigma and higher rates of HIV infections among groups such as Latino and Black gay and bisexual men compound the need for more attention on HIV during Pride Month. Working to combat the stigma surrounding HIV and AIDS and promoting information about prevention and care can deepen the meaning behind Pride, making the entire month even more impactful. Promoting community-led carePride Month opens doors for inclusive, community-led advocacy and care in 2025, especially for those in areas of the country with higher rates of HIV infections and a greater need for access to prevention methods. HIV advocacy and care in 2025 looks like cultural understanding, expanded accessibility, and leadership in individual communities and the broader LGBTQ+ community. Partnerships between advocacy groups, community leaders, and health organizations are crucial for achieving the goals we must set each Pride Month. These goals should include reducing stigma and expanding educational resources, especially in areas heavily impacted by the disease, such as the Southern United States.New care models highlighted during Pride Month must be inclusive of the communities most impacted by HIV today and tailored to diverse experiences across those communities. One mission of Pride Month is the building of trust between community leaders, advocacy groups, and health organizations and those who need the most attention, such as those living with HIV or AIDS.Pride must not only be a month for education and advocacy, but also for recognizing those who have participated in making HIV an increasingly manageable condition. So many in the LGBTQ+ community are living long, healthy lives with HIV. That in and of itself is worthy of celebration. Honoring the roots of Pride MonthPride indeed began as a riot a collective uprising against discrimination, hate, and inequity. As the HIV/AIDS epidemic took hold, the continued need for collective work toward a better future was evident.Today, Pride is still an uprising. Keeping HIV awareness and prevention at the heart of Pride Month deepens its mission and continues the promise that no one in the LGBTQ+ community will be left behind or forgotten, in June or any other time.As we celebrate flying the rainbow flag, marching in parades, and participating in all that makes Pride wonderful, its crucial to remember that Pride Month can also be a time of deeper significance. The reality of HIV persists, and Pride Month can be a time to shine a greater spotlight on what still needs to be done to protect the LGBTQ+ community and take greater strides toward eliminating HIV once and for all.By weaving stigma-fighting prevention campaigns and collaborative efforts between community leaders and health organizations into the celebratory mission of Pride Month, more progress can be made in prevention and care.Subscribe to theLGBTQ Nation newsletterand be the first to know about the latest headlines shaping LGBTQ+ communities worldwide.